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Telaglenastat is currently in a Phase II clinical trial, testing the effectiveness of its combination with talazoparib, a poly-ADP ribose polymerase (PARP) inhibitor, in mCRPC patients (ClinicalTrial.gov ID NCT04824937)
After validating asthma-association metabolic pathways via global metabolomics, we selected steroids, sphingolipids, and microbial-derived metabolites for detailed investigation using targeted assays, ultimately focusing on the relationship between steroid and sphingolipid metabolism and 5-year asthma exacerbation risk
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It is recommended to follow up these patients closely to understand the natural history to develop better recommendations for management
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